News

ï»ż

June 2021

Study published: Transglutaminase 2 promotes colon cancer cell survival - congrats to Patrizia and Ilaria

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June 2021

Esther defended her thesis - Well done Dr. med.!

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May 2021

Michael published Editorial on CHIP

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March 2021

New study published on clonal hematopoiesis - big congrats to Katharina

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Jan 2021

Lena successfully defended her thesis - congrats Dr. Dorsheimer

Nov 2020

Alec Gessner joint the team as PhD student - welcome Alec!

July 2020

New positions available in the lab!

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June 2020

Fighting COVID19 - support by Goethe Corona Fonds

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April 2020

Joining the BD MultiOmics Alliance

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March 2020

New PhD Student positions available!

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Jan 2020

New Review on Clonal Hematopoiesis (CHIP) published

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Dec 2019

Frankfurt University highlights our latest research

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Nov 2019

Lena published bone marrow alterations in CHIP carriers - congrats!

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Oct 2019

Editorial on NATURE paper about stem cell expansion by Michael

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Oct 2019

Ilaria successfully defended her thesis - congrats Dr. Lunger

Oct 2019

Rene received MD stipent from the JackstÀdt-Stiftung at the DGHO - congrats!

Sept 2019

Our CHIP Team scored again - EHJ publication!

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May 2019

ChristinaÂŽs paper about CHIP after autoSCT published in Cell Reports - congrats!

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Jan 2019

New lab positions available (PhD, Postdoc, TA)

Dec 2018

Clonal hematopoiesis contribute to ischemic heart failure - published in JAMA Cardiology

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Dec 2018

New TA position available

Dec 2018

New Postdoc position available

Nov 2018

Public Report about Rieger Lab

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Sept 2018

Excellence Cluster Cardio-Pulmonary-Institute funded!

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Aug 2018

Michael invited speaker at ISEH 2018 in Los Angeles

June 2018

New PostDoc position available

Feb 2018

MiRNA-193b in AML - great story published in JCO

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Dec 2017

Bartosch successfully defended his thesis - congrats Dr. Wojcik

Dec 2017

Bartosch and Fabian published Perspective Article in ONCOTARGET

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ï»ż 2021

Lazaro-Navarro, J., Pimentel-Gutiérrez, H.J., Gauert, A., Hagemann, A., Eisenschmid, J.L., Goekbuget, N., Vick, B., Jeremias, I., Seyfried, F., Meyer, L.H., Debatin, K.-M., Richter, K., Bultmann, M., Neumann, M., Haenzelmann, S., Serve, H., Astrahantseff, K., Rieger, M.A., Eckert, C., Baldus, C.D., Bastian, L. (2021)
Inhibiting Casein Kinase 2 Sensitizes Acute Lymphoblastic Leukemia Cells to Venetoclax Via MCL1 Degradation.
BLOOD Adv. [Epub ahead of print]
> pubmed

Enssle, J.C., Campe, J., Schwenger, A., Wiercinska, E., Hellstern, H., DĂŒrrwald, R., Rieger, M.A., Wolf, S., Ballo, O., Steffen, B., Serve, H., Bonig, H., Rabenau, H.F., Widera, M., Ciesek, S., Metzler, I., Ullrich, E. (2021)
Severe impairment of T-cell responses to BNT162b2 immunization in multiple myeloma patients.
BLOOD [Epub ahead of print]
> pubmed

Malkomes, P.*, Lunger, I.*, Oppermann, E., Abou-El-Ardat, K., Oellerich, T., GĂŒnther, S., Canbulat, C., Bothur, S., SchnĂŒtgen, F., Yu, W., Wingert, S., Haetscher, N., Catapano, C., Dietz, M.S., Heilemann, M., Kvasnicka, H.-M., Holzer, K., Serve, H., Bechstein, W. O., Rieger, M.A. (2021)
Transglutaminase 2 promotes tumorigenicity of colon cancer cells by inactivation of the tumor suppressor p53.
Oncogene [Epub ahead of print]
* shared first authorship
> pubmed

Schmidt, J., Oppermann, E., Blaheta, R.A., Schreckenbach, T., Lunger, I., Rieger, M.A., Bechstein, W.O., Holzer, K., Malkomes, P. (2021)
Carbonic-anhydrase IX expression is increased in thyroid cancer tissue and represents a potential therapeutic target to eradicate thyroid tumor-initiating cells.
Mol Cell Endocrinol [Epub ahead of print]
> pubmed

Rieger, M.A (2021)
A heartbreaking relationship: clonal hematopoiesis and heart failure.
Trends Cardiovasc Med [Epub ahead of print]
> pubmed

Le Mercier, A., Bonnavion, R., Yu, W., Alnouri, M.W., Ramas, S., Zhang, Y., JĂ€ger, Y., Roquid, K.A., Jeong, H.-W., Sivaraj, K.K., Cho, H, Chen, X., Strilic, B., Sijmonsma, T., Adams, R., Schroeder, T., Rieger, M.A., Offermanns, S. (2021)
GPR182 is an endothelium-specific atypical chemokine receptor that maintains hematopoietic stem cell homeostasis.
Proc Natl Acad Sci U S A 118(17):e2021596118.
> pubmed

Kiefer, K.C., Cremer, S., Pardali, E., Assmus, B., Abou-El-Ardat, K., Kirschbaum, K., Dorsheimer, L., Rasper, T., Berkowitsch, A., Serve, H., Dimmeler, S.*, Zeiher, A.M.*, Rieger, M.A* (2021)
Full spectrum of clonal haematopoiesis‐driver mutations in chronic heart failure and their associations with mortality.
ESC Heart Failure [Epub ahead of print]
* shared last authorship
> pubmed

Abplanalp, W.T., John, D., Cremer, S., Assmus, B., Dorsheimer, L., Hoffmann, J., Becker-Pergola, G., Rieger, M.A., Zeiher, A.M., Vasa-Nicotera, M., Dimmeler, S. (2021)
Single cell RNA sequencing reveals profound changes in circulating immune cells in patients with heart failure.
Cardiovasc. Res. 117(2):484-494.
> pubmed

2020

Assmus, B., Cremer, S., Kirschbaum, K., Culmann, D., Kiefer, K., Dorsheimer, L., Rasper, T., Abou-El-Ardat, K., Herrmann, E., Berkowitsch, A., Hoffmann, J., Seeger, F., Mas-Peiro, S., Rieger, M.A., Dimmeler, S., Zeiher, A.M. (2020)
Clonal haematopoiesis in chronic ischaemic heart failure: prognostic role of clone size for DNMT3A- and TET2-driver gene mutations.
Eur. Heart J. [Epub ahead of print]
> pubmed

Abplanalp, W.T., Cremer, S., John, D., Hoffmann, J., Schuhmacher, B., Merten, M., Rieger, M.A., Vasa-Nicotera, M., Zeiher, A.M., Dimmeler, S. (2020)
Clonal Hematopoiesis-Driver DNMT3A Mutations Alter Immune Cells in Heart Failure.
Circ. Res. [Epub ahead of print]
> pubmed

Lauber, C., Correia, N., Trumpp, A., Rieger, M.A., Dolnik, A., Bullinger, L., Roeder, I., Seifert, M. (2020)
Survival differences and associated molecular signatures of DNMT3A-mutant acute myeloid leukemia patients.
Sci Rep 10(1):12761-77.
> pubmed

Sommerkamp, P., Altamura, S., Renders, S., Narr, A., Ladel, L., Zeisberger, P., Eiben, P.L., Fawaz, M., Rieger, M.A., Cabezas-Wallscheid, N., Trumpp, A. (2020)
Differential Alternative Polyadenylation Landscapes Mediate Hematopoietic Stem Cell Activation and Regulate Glutamine Metabolism.
Cell Stem Cell 26(5):722-738.
> pubmed

Pardali, E., Dimmeler, S., Zeiher, A.M., Rieger, M.A.# (2020)
Clonal hematopoiesis, aging, and cardiovascular diseases.
Exp. Hematol. 83:95-104.
> pubmed

Mas-Peiro, S., Hoffmann, J., Fichtlscherer, S., Dorsheimer, L., Rieger, M.A., Dimmeler, S., Vasa-Nicotera, M., and Zeiher A.M. (2020)
Clonal haematopoiesis in patients with degenerative aortic valve stenosis undergoing transcatheter aortic valve implantation.
European Heart Journal , 41(8):933-939
> pubmed

Dorsheimer, L.*, Assmus, B.*, Rasper, T., Ortmann, C.A., Abou-El-Ardat, K., Kiefer, K.C., Hoffmann, J., Seeger, F., Bonig, H., Dimmeler, S.#, Zeiher, A.M.#, Rieger, M.A.# (2020)
Hematopoietic alterations in chronic heart failure patients by somatic mutations leading to clonal hematopoiesis.
Haematologica e328-e332.
* shared first authorship
# shared senior authorship
> pubmed

2019

Rieger, M.A.*. (2019)
How children’s glue fixes a decades old enigma.
Annal. Transl. Med. doi: 10.21037/atm.2019.09.90
> pubmed

Ortmann, C.A., Dorsheimer, L., Abou-El-Ardat. K., Hoffrichter, J., Assmus, B., Bonig, H., Scholz, A., Pfeifer, H., Martin, H., Schmid, T., BrĂŒne, B., Scheich, S., Steffen, B., Riemann, J., Hermann, S., Dukat, A., Bug, G., Brandts, C.H., Wagner, S., Serve, H., Rieger, M.A. (2019)
Functional Dominance of CHIP-Mutated Hematopoietic Stem Cells in Patients Undergoing Autologous Transplantation.
Cell Rep 27(7):2022-2028.e3.
> pubmed

Bastian, L., Schroeder, M.P., Eckert, C., Schlee, C., Tanchez, J.O., KĂ€mpf, S., Wagner, D.L., Schulze, V., Isaakidis, K., LĂĄzaro-Navarro, J., HĂ€nzelmann, S., James, A.R., Ekici, A., Burmeister, T., Schwartz, S., Schrappe, M., Horstmann, M., Vosberg, S., Krebs, S., Blum, H., Hecht, J., Greif, P.A., Rieger, M.A., BrĂŒggemann, M., Gökbuget, N., Neumann, M., Baldus, C.D. (2019)
PAX5 biallelic genomic alterations define a novel subgroup of B-cell precursor acute lymphoblastic leukemia.
Leukemia 33(8):1895-1909.
> pubmed

Diefenhardt, M., Hofheinz, R.D., Martin, D., Beißbarth, T., Arnold, D., Hartmann, A., von der GrĂŒn, J., GrĂŒtzmann, R., Liersch, T., Ströbel, P., Grabenbauer, G.G., Rieger, M., Fietkau, R., Graeven, U., Weitz, J., Folprecht, G., Ghadimi, M., Rödel, F., Rödel, C., Fokas, E.; German Rectal Cancer Study Group. (2019)
Leukocytosis and neutrophilia as independent prognostic immunological biomarkers for clinical outcome in the CAO/ARO/AIO-04 randomized phase 3 rectal cancer trial.
Int. J. Cancer 145(8):2282-2291.
> pubmed

Schroeder, M.P., Bastian, L., Eckert, C., Gökbuget, N., James, A.R., Tanchez, J.O., Schlee, C., Isaakidis, K., HĂ€upl, B., Baum, K., Migueles Lozano, O.A., Kouidri, K., Pan, K.T., Urlaub, H., Schwartz, S., Burmeister, T., von Stackelberg, A., Hoelzer, D., Pfeiffer, H., Rieger, M.A., Göllner, S., Oellerich, T., Horstman, M., Schrappe, M., Wolf, J., Kirschner-Schwabe, R., BrĂŒggemann, M., MĂŒller-Tidow, C., Serve, H., Neumann, M., Baldus, C.D. (2019)
Integrated analysis of relapsed B-cell precursor Acute Lymphoblastic Leukemia identifies subtype-specific cytokine and metabolic signatures.
Sci. Rep. 12;9(1):4188.
> pubmed

Dorsheimer, L.*, Assmus, B. *, Rasper, T., Ortmann, C.A., Ecke, A., Abou-El-Ardat, K., Schmid, T., BrĂŒne, B., Wagner, S., Serve, H., Hoffmann, J., Seeger, F., Dimmeler, S.#, Zeiher, A.M.#, Rieger, M.A.# (2019)
Association of Mutations Contributing to Clonal Hematopoiesis With Prognosis in Chronic Ischemic Heart Failure.
JAMA Cardiol. 4:25-33.
* shared first authorship
# shared senior authorship
> pubmed
Editorial > link
Interview > link
Editorial Nat Rev Cardiol > link

James, A.R., Schroeder, M.P., Neumann, M., Bastian, L., Eckert, C., Gökbuget, N., Tanchez, J.O., Schlee, C., Isaakidis, K., Schwartz, S., Burmeister, T., von Stackelberg, A., Rieger, M.A., Göllner, S., Horstman, M., Schrappe, M., Kirschner-Schwabe, R., BrĂŒggemann, M., MĂŒller-Tidow, C., Serve, H., Akalin, A., Baldus, C.D. (2019)
Long non-coding RNAs defining major subtypes of B cell precursor acute lymphoblastic leukemia.
J Hematol Oncol. 12:8.
> pubmed

2018

Debaize, L., Jakobczyk, H., Avner, S., Gaudichon, J., Rio, A.G., Sérandour, A.A., Dorsheimer, L., Chalmel, F., Carroll, J.S., Zörnig, M., Rieger, M.A., Delalande, O., Salbert, G., Galibert, M.D., Gandemer, V., Troadec, M.B. (2018)
Interplay between transcription regulators RUNX1 and FUBP1 activates an enhancer of the oncogene c-KIT and amplifies cell proliferation.
Nucleic Acids Res. 46:11214-28.
> pubmed

Bhayadia, R.*, , Krowiorz, K.*, Haetscher, N.*, Jammal, R.*, Emmrich, S.*, Obulkasim, A. Fiedler, J., Schwarzer, A., Rouhi, A., Heuser, M., Wingert, S., Bothur, S., Döhner, K., MÀtzig, T., Ng, M., Reinhardt, D., Döhner, H., Zwaan, C. M., van den Heuvel-Eibrink, M. M., Heckl, D., Fornerod, M., Thum, T., Humphries, R. K., Rieger, M. A.#, Kuchenbauer, F.#, Klusmann, J.-H.#. (2018)
The endogenous tumor suppressor microRNA-193b: therapeutic and prognostic value in acute myeloid leukemia.
J Clin Oncol 36:1007-1016
* shared first authorship
# shared senior authorship
> pubmed

Cencioni, C., Spallotta, F., Savoia, M., Kuenne, C., Guenther, S., Re, A., Wingert, S., Rehage, M., SĂŒrĂŒn, D., Siragusa, M., Smith, J.G., SchnĂŒtgen, F., von Melchner, H., Rieger, M.A., Martelli, F., Riccio, A., Fleming, I., Braun, T., Zeiher, A.M., Farsetti, A., Gaetano, C. (2018)
Zeb1-Hdac2-eNOS circuitry identifies early cardiovascular precursors in naĂŻve mouse embryonic stem cells.
Nat Commun 9:1281.
> pubmed

Laban, H., Weigert, A., Zink, J., Elgheznawy, A., SchĂŒrmann, C., GĂŒnther, L., Abdel Malik, R., Bothur, S., Wingert, S., Bremer, R., Rieger, M.A., BrĂŒne, B., Brandes, R.P., Fleming, I., Benz, P.M. (2018)
VASP regulates leukocyte infiltration, polarization, and vascular repair after ischemia.
J Cell Biol 217:1503-1519.
> pubmed

Manavski, Y, Lucas, T., Glaser, S.F., Dorsheimer, L., GĂŒnther, S., Braun, T., Rieger, M.A., Zeiher, A.M., Boon, R.A., Dimmeler, S. (2018)
Clonal Expansion of Endothelial Cells Contributes to Ischemia-Induced Neovascularization.
Circ Res 122:670-677.
> pubmed

2017

Wojcik, B., Lang, F., and Rieger, M.A.. (2017)
On the hunt for B-cell lymphoblastic leukemia-initiating stem cells.
Oncotarget 8:108286-108287.
> pubmed

Rezende, F., Moll, F., Walter, M., Helfinger, V., Hahner, F., Janetzko, P., Ringel, Ch., Weigert, A., Fleming, I., Weissmann, N., Kuenne, C., Looso, M., Rieger, M.A., Nawroth, P., Fleming, Th., Brandes, R., Schröder, K. (2017)
The NADPH organizers NoxO1 and p47phox are both mediators of diabetes-induced vascular dysfunction in mice.
Redox Biol 15:12-21.
> pubmed

Lunger, I.*, Fawaz, M.*, and Rieger, M.A.. (2017)
Single cell analyses to reveal hematopoietic stem cell fate decisions.
FEBS Lett 591:2195-2212.
* shared first authorship
> pubmed

Cabezas-Wallscheid, N., Buettner, F., Sommerkamp, P., Klimmeck, D., Ladel, L., Thalheimer, F.B., Pastor-Flores, D., Roma, L., Renders, S., Zeisberger, P., Przybylla, A., Schönberger, K., Scognamiglio, R., , Altamura, S., Florian, C., Fawaz, M., Vonficht, D., Tesio, M., Collier, P., Pavlinic, D., Geiger, H., Schroeder., T., Benes, V., Dick, T.P., Rieger, M.A., Stegle, O. and Trumpp, A. (2017)
Vitamin A-Retinoic Acid Signaling Regulates Hematopoietic Stem Cell Dormancy.
Cell 169:807-823.
> pubmed

Mohr, S., Doebele, C., Comoglio, F., Berg, T., Beck, J., Bohnenberger, H., Alexe, G., Corso, J., Ströbel, P., Wachter, A., Beissbarth, T., SchnĂŒtgen, F., Cremer, A., Haetscher, N., Göllner, S., Rouhi, A., Palmqvist, L., Rieger, M.A., Schroeder, T., Bönig, H., MĂŒller-Tidow, C., Kuchenbauer, F., SchĂŒtz, E., Green, A.R., Urlaub, H., Stegmaier, K., Humphries, R.K., Serve, H., Oellerich, T. (2017)
Hoxa9 and Meis1 Cooperatively Induce Addiction to Syk Signaling by Suppressing miR-146a in Acute Myeloid Leukemia.
Cancer Cell 31:549-562.
> pubmed

Wesely, J., Steiner, M., SchnĂŒtgen, F., Kaulich, M., Rieger, M.A., Zörnig, M. (2017)
Delayed Mesoderm and Erythroid Differentiation of Murine Embryonic Stem Cells in the Absence of the Transcriptional Regulator FUBP1.
Stem Cells Int. 2017:5762301
> pubmed

Lang, F.*, Wojcik, B.*, Bothur S., Knecht, C., Falkenburg, J.H.F., Schroeder, T., Serve, H., Ottmann, O.G., Rieger, M.A. (2017)
Plastic CD34 and CD38 expression in adult B-cell precursor acute lymphoblastic leukemia explains ambiguity of leukemia-initiating stem cell populations.
Leukemia 31:731–734.
* shared first authorship
> pubmed

Malik, R.A., Zippel, N., Frömel, T., Heidler, J., Zukunft, S., Walzog, B., Ansari, N., Pampaloni, F., Wingert, S., Rieger, M.A., Wittig, I., Fisslthaler, B., Fleming, I. (2017)
AMP-activated protein kinase α2 in neutrophils regulates vascular repair via hypoxia-inducible factor-1α and a network of proteins affecting metabolism and apoptosis.
Circ Res 120:99-109.
> pubmed

Latorre-Rey, L.J., Wintterle, S., DĂŒtting, S., Kohlscheen, S., Abel, T., Schenk, F., Wingert, S., Rieger, M.A., Nieswandt, B., Heinz, N., Modlich, U. (2017)
Targeting expression to megakaryocytes and platelets by lineage-specific lentiviral vectors.
J Thromb Haemost 15:341-355.
> pubmed

SteinhÀuser, K., Klöble, P., Kreis, N.-N., Ritter, A., Friemel, A., Roth, S., Reichel, J.M., Michaelis, J., Rieger, M.A., Louwen, F., Oswald, F. and Yuan J. (2017)
Deficiency of RITA results in multiple mitotic defects by affecting microtubule dynamics.
Oncogene 36:2146-2159.
> pubmed

2016

Hoppe, P.S., Schwarzfischer, M., Loeffler, D., Kokkaliaris, K.D., Hilsenbeck, O., Moritz, N., Endele, M., Filipczyk, A., Gambardella, A., Ahmed, N., Etzrodt, M., Coutu, D.L., Rieger, M.A., Marr, C., Strasser, M.K., Schauberger, B., Burtscher, I., Ermakova, O., BĂŒrger, A., Lickert, H., Nerlov, C., Theis, F.J., Schroeder, T. (2016)
Early myeloid lineage choice is not initiated by random PU.1 to GATA1 protein ratios.
Nature 535(7611):299-302.
> pubmed

Corso, J., Pan, K.T., Walter, R., Doebele, C., Mohr, S., Bohnenberger, H., Ströbel, P., Lenz, C., Slabicki, M., HĂŒllein, J., Comoglio, F., Rieger, M.A., Zenz, T., Wienands, J., Engelke, M., Serve, H., Urlaub, H., Oellerich, T. (2016)
Elucidation of tonic and activated B-cell receptor signaling in Burkitt's lymphoma provides insights into regulation of cell survival.
Proc Natl Acad Sci U S A. 113(20):5688-93.
> pubmed

Kreis, N.-N., Friemel, A., Zimmer, B., Roth, S., Rieger, M.A., Rolle, U., Louwen, F., and Yuan, J. (2016)
Mitotic p21Cip1/CDKN1A is regulated by cyclin-dependent kinase 1 phosphorylation.
Oncotarget 7:50215-50228.
> pubmed

Wingert, S., Rieger, M.A. (2016)
Terminal differentiation induction as DNA damage response in hematopoietic stem cells by GADD45A.
Exp Hematol. 44:561-6.
> pubmed

Derlet, A., Rasper, T., Roy Choudhury, A., Bothur, S., Rieger, M.A., Namgaladze, D., Fischer, A., SchĂŒrmann, C., Brandes, R.P., Tschulena, U., Steppan, S., Assmus, B., Dimmeler, S., Zeiher, A.M., and Seeger, F.H. (2016)
Metabolism Regulates Cellular Functions of Bone Marrow-Derived Cells used for Cardiac Therapy.
Stem Cells 34:2236-48.
> pubmed

Malkomes, P., Lunger, I., I., Luetticke, A., Oppermann, E., Haetscher, N., Serve, H., Holzer, K., Bechstein, W.O. and Rieger, M.A. (2016)
Selective AKT inhibition by MK-2206 represses colorectal cancer-initiating stem cells.
Ann Surg Oncol 23:2849-57.
> pubmed

Wingert, S., Thalheimer, F.B., Haetscher, N., Rehage, M., Schroeder, T., and Rieger, M.A. (2016)
The DNA-damage response gene GADD45A induces differentiation in hematopoietic stem cells without inhibiting cell cycle or survival.
Stem Cells 34:699-710.
> pubmed

2015

Haetscher, N.*, Feuermann, Y.*, Wingert, S., Rehage, M., Thalheimer, F.B., Weiser, C., Bohnenberger, H., Jung, K., Schroeder, T., Serve, H., Oellerich, T., Hennighausen, L., and Rieger, M.A. (2015)
STAT5-regulated microRNA-193b controls haematopoietic stem and progenitor cell expansion by modulating cytokine receptor signalling.
Nature Commun. 6:8928.
* shared first authorship
> pubmed

Rieger, M.A. (2015)
ATF4, a new player in fetal HSC expansion.
Blood. 126 (21):2351-52.
> pubmed

Lang, F., Wojcik, B., and Rieger, M.A. (2015)
Stem Cell Hierarchy and Clonal Evolution in Acute Lymphoblastic Leukemia.
Stem Cells Int. 2015:137164
> pubmed

Rabenhorst, U.*, Thalheimer, F.B.*, Gerlach, K.*, Kijonka, M., Böhm, S., Krause, D., Vauti, F., Arnold, HH., Schroeder, T., SchnĂŒtgen, F., von Melchner, H., Rieger, M.A.#, and Zörnig, M#. (2015)
Single-stranded DNA-binding transcriptional regulator FUBP1 is essential for fetal and adult hematopoietic stem cell self-renewal.
Cell Reports 11(12):1847-55.
* shared first authorship
# shared senior authorship
> pubmed

Zhang, J., Vakhrusheva,O., Bandi, S.R., Demirel, Ö., Kazi,J.U., Fernandes, R.G., Jakobi, K., Eichler, A., Rönnstrand, L., Rieger, M.A., Carpino, N., Serve, H., and Brandts, C.H. (2015)
STS1 and STS2 are key regulators of hematopoietic stem and progenitor cell fitness.
Stem Cell Rep 5(4):633-46.
> pubmed

Kuvardina, O.N., Herglotz, J., Kolodziej, S., Kohrs, N., Herkt, S., Wojcik, B., Oellerich, T., Corso, J., Behrens, K., Kumar, A., Hussong, H., Urlaub, H., Koch, J., Serve, H., Bonig, H., Stocking, C., Rieger, M.A. and Lausen, J. (2015)
RUNX1 represses the erythroid gene expression program during megakaryocytic differentiation.
BLOOD 125(23):3570-9.
> pubmed

Walter, D., Lier, A., Geiselhart, A., Thalheimer, F.B., Huntscha, S., Sobotta, M., Moehrle, B., Brocks, D., Bayindir, I., Kaschutnig, P., Muedder, K., Klein, C., Jauch, A., Schroeder, T., Geiger, H., Dick, T., Holland-Letz, T., Schmezer, P., Lane, S., Rieger, M.A. Essers, M., Williams, D., Trumpp, A., and Milsom, M. (2015)
Exit from dormancy provokes de novo DNA damage-induced cellular attrition in haematopoietic stem cells.
Nature 520(7548):549-52.
> pubmed

Meinhardt, K., Kroeger, I., Bauer, R., Ganss, F., Ovsiy, I., Rothamer, J., BĂŒttner, M., Atreya, I., Waldner, M., Bittrich, M., Lehmann, C.H., Rieger, M.A., Beilhack, A., Zeiser, R., Edinger, M., Dudziak, D., Mackensen, A., Rehli, M., and Ullrich, E. (2015)
Identification and characterization of the specific murine NK cell subset supporting graft-versus-leukemia- and reducing graft-versus-host-effects.
Oncoimmunology 4(1):e981483.
> pubmed

2014

Schönfeld, K., Sahm. C., Zhang, C., Naundorf, S., Brendel, C., Odendahl, M., Nowakowska, P., Bönig, H., Köhl, U., Kloess, S., Köhler, S., Holtgreve-Grez, H., Jauch, A., Schmidt, M., Schubert, R., KĂŒhlcke, K., Seifried, E., Klingemann, H.G., Rieger, M.A., Tonn, T., Grez, M., Wels, W.S. (2014)
Selective Inhibition of Tumor Growth by Clonal NK Cells Expressing an ErbB2/HER2-Specific Chimeric Antigen Receptor
Mol Ther 23(2):330-8.
> pubmed

Thalheimer, F.B., Wingert, S., De Giacomo, P., Haetscher, N., Rehage, M., Brill, B., Theis, F.J., Hennighausen, L., Schroeder, T., Rieger, M.A. (2014)
Cytokine-Regulated GADD45G Induces Differentiation and Lineage Selection in Hematopoietic Stem Cells
Stem Cell Reports 3(1):34-43.
> pubmed

Rengstl, B., Rieger, M.A.*, Newrzela, S.* (2014)
On the origin of giant cells in Hodgkin lymphoma
Communicative & Integrative Biology 7:I, e28602.
* shared last authorship
> pubmed

Rengstl, B., Newrzela, S., Heinrich, T., Weiser, C., Thalheimer, F.B., Schmid, F., Warner, K., Hartmann, S., Schroeder, T., KĂŒppers, R., Rieger, M.A.*, Hansmann, M.L.* (2013)
Incomplete cytokinesis and re-fusion of small mononucleated Hodgkin cells lead to giant multinucleated Reed-Sternberg cells.
Proc Natl Acad Sci U S A. 110:20729-34.
* shared last authorship
> pubmed

Feuermann, Y., Kang, K., Gavrilova, O., Haetscher, N., Jin Jang, S., Yoo, K.H., Jiang, C., Gonzalez, F.J., Robinson, G.W., Hennighausen, L. (2013)
MiR-193b and miR-365-1 are not required for the development and function of brown fat in the mouse.
RNA Biol. [Epub ahead of print]
> pubmed

Kreis, N.N., Sanhaji, M., Rieger, M.A., Louwen, F., Yuan, J. (2013)
p21Waf1/Cip1 deficiency causes multiple mitotic defects in tumor cells.
Oncogene. [Epub ahead of print]
> pubmed

Ohtani, K., Zhao, C., Dobreva, G., Manavski, Y., Kluge, B., Braun, T., Rieger, M.A., Zeiher, A.M., Dimmeler, S. (2013)
Jmjd3 Controls Mesodermal and Cardiovascular Differentiation of Embryonic Stem Cells.
Circ Res. 113:856-62.
> pubmed

Oellerich, T., Oellerich, M.F., Engelke, M., MĂŒnch, S., Mohr, S., Nimz, M., Hsiao, H.H., Corso, J., Zhang, J., Bohnenberger, H., Berg, T., Rieger, M.A., Wienands, J., Bug, G., Brandts, C., Urlaub, H., and Serve, H. (2013)
ß2 integrin-derived signals induce cell survival and proliferation of AML blasts by activating a Syk/STAT signaling axis.
Blood, 121:3889-99.
> pubmed

Rieger, M.A. and Schroeder, T. (2012)
Hematopoiesis.
Cold Spring Harb Perspect Biol 4:a008250. Editors: Patrick P.L. Tam, W. James Nelson, and Janet Rossant
> pubmed

Eißmann, M., Melzer, I.M., FernĂĄndez, S.B., Michel, G., Hrabe de Angelis, M., Hoefler, G., Finkenwirth, P., Jauch, A., Schoell, B., Grez, M., Schmidt, M., Bartholomae, C.C., Newrzela, S.,Haetscher, N., Rieger, M.A., Zachskorn, C., Mittelbronn, M. and Zörnig, M. (2012)
Overexpression of the anti-apoptotic protein AVEN contributes to increased malignancy in hematopoietic neoplasms.
Oncogene [Epub ahead of print]
> pubmed

Ninkovic, J., Pinto, L., Petricca, S., Lepier, A., Sun, J., Rieger, M.A., Schroeder, T., Cvekl, A., Favor, J. and Götz, M. (2010)
The transcription factor Pax6 regulates survival of dopaminergic olfactory bulb neurons via crystallin a.
Neuron, 68: 682-94.
> pubmed

Rieger, M.A. and Schroeder, T. (2009)
Instruction of lineage choice by hematopoietic cytokines.
Cell Cycle, 8: 4019 – 4020.
> pubmed

Rieger, M.A., Hoppe, P.S., Smejkal, B.M., Eitelhuber, A.C. and Schroeder, T. (2009)
Hematopoietic cytokines can instruct lineage choice.
Science, 325: 217-218.
> pubmed

(P)Reviews in scientific journals:

Kimura, A.*, Rieger, M.A.*, Simone, J.M., Chen, W., Wickre, M.C., Zhu, B.-M., Hoppe, P.S., O’Shea, J., Schroeder, T.** and Hennighausen, L.** (2009)
The transcription factors STAT5A/B regulate GM-CSF-mediated granulopoiesis.
Blood, 114: 4721-8.
* and ** equal contributions
> pubmed

Rieger, M.A. and Schroeder, T. (2009)
Analysing cell fate control by cytokines through continuous single cell biochemistry.
Journal of Cellular Biochemistry, 108: 343 – 352.
> pubmed

Rieger, M.A., Smejkal, B.M. and Schroeder T (2009)
Improved prospective identification of megakaryocyte-erythrocyte progenitor cells.
British Journal of Haematology, 144: 448 – 451.
> pubmed

Rieger, M.A. and Schroeder, T. (2008)
Exploring hematopoiesis at single cell resolution.
Cells Tissues Organs, 188: 139-49.
> pubmed

Arakawa, H., Kudo, H., Batrak, V., Caldwell, R.B., Rieger, M.A., Ellwart, J.W. and Buerstedde, J.M. (2007)
Protein evolution by hypermutation and selection in the B cell line DT40.
Nucleic Acids Research, 36:e1.
> pubmed

Rieger M.A. and Schroeder, T. (2007)
HĂ€matopoetische Stammzellen, Review (German).
Biospektrum, 3.2007: 254-256.
> pubmed

Schmitz, M., Wehner, R., Stevanovic, S., Kießling, A., Rieger M.A., Temme, A., Bachmann, M., Rieber, E.P., and Weigle, B. (2007)
Identification of a naturally processed T cell epitope derived from the glioma-associated protein SOX11.
Cancer Lett. 245: 331-6.
> pubmed

Cappello, S., Attardo, A., Wu, X., Iwasato, T., Itohara, S., Wilsch-Brauninger, M., Eilken, H.M., Rieger M.A., Schroeder, T.T., Huttner, W.B., Brakebusch, C., and Gotz, M. (2006)
The Rho-GTPase cdc42 regulates neural progenitor fate at the apical surface.
Nature Neuroscience 9, 1099-107.
> pubmed

Weigle, B., Ebner, R., Temme, A., Schwind, S., Schmitz, M., Kiessling, A., Rieger M.A., Schackert, G., Schackert, H.K., and Rieber, E.P. (2005)
Highly specific overexpression of the transcription factor SOX11 in human malignant gliomas.
Oncol. Rep., 13, 139-144
> pubmed

Temme, A., Morgenroth, A., Diestelkoetter-Bachert, P., Weigle, B., Rieger M.A., Kiessling, A., Schmitz, M., and Rieber, E.P. (2005)
Increased p21ras activity in human fibroblasts transduced with Survivin enhances cell proliferation.
Biochem. Biophys. Res. Commun., 327, 765-773.
> pubmed

Temme, A., Herzig, E., Weigle, B., Morgenroth, A., Schmitz, M., Kiessling, A., Rieger, M.A., Schackert, H.K., and Rieber, E.P. (2005)
Inhibition of malignant glioma cell growth by a survivin mutant retrovirus.
Hum. Gene. Ther., 16, 209-222.
> pubmed

Schmitz, M., Zhao, S., Deuse, Y., SchÀkel, K., Wehner, R., Wöhner, H., Hölig, K., Wienforth, F., Kiessling, A., BornhÀuser, M., Temme, A., Rieger, M.A., Weigle, B., Bachmann, M., and Rieber, E.P. (2005)
Tumoricidal potential of native blood dendritic cells: direct tumor cell killing and activation of NK cell-mediated cytotoxicity.
J. Immunol., 174, 4127-4134.
> pubmed

Kiessling, A., Weigle, B., FĂŒssel, S., Ebner, R., Meye, A., Rieger, M.A., Schmitz, M., Temme, A., Bachmann, M., Wirth, M.P., and Rieber, E.P. (2005)
D-TMPP: a novel androgen-regulated gene preferentially expressed in prostate and prostate cancer that is the first characterised member of an eukaryotic gene family.
Prostate, 64, 387-400.
> pubmed

Rieger, M.A. , Ebner, R., Bell , D.R., Kiessling, A., Rohayem, J., Schmitz, M., Temme, A., Rieber, E.P., and Weigle, B. (2004)
Identification of a novel mammary-restricted cytochrome P450, CYP4Z1, with overexpression in breast carcinoma.
Cancer Res., 64, 2357-2364.
> pubmed

Kiessling, A., Stevanovic, S., FĂŒssel, S., Weigle, B., Rieger, M.A., Temme, A., Rieber, E.P., and Schmitz, M. (2004)
Identification of an HLA-A*0201-restricted T cell epitope derived from the prostate cancer-associated protein prostein.
Br. J. Cancer, 90, 1034-1040.
> pubmed

Weigle, B., Kiessling, A., Ebner, R., Fuessel, S., Temme, A., Schmitz, M., Rieger, M.A., Ockert, D., Wirth, M.P., and Rieber, E.P. (2004)
D-PCa-2: a novel transcript specifically expressed in human normal prostate and prostate cancer.
Int. J. Cancer, 109, 882-892.
> pubmed

Weigle, B., Fuessel, S., Ebner, R., Temme, A., Schmitz, M., Schwind, S., Kiessling, A., Rieger, M.A., Meye, A., Bachmann, M., Wirth, M.P., and Rieber, E.P. (2004)
D-GPCR: a novel putative G protein-coupled receptor overexpressed in prostate cancer and prostate.
Biochem. Biophys. Res. Commun. , 322, 239-249.
> pubmed

Temme, A., Rieger, M., Reber, F., Lindemann, D., Weigle, B., Diestelkoetter-Bachert, P., Ehninger, G., Tatsuka, M., Terada, Y., and Rieber, E.P. (2003)
Localisation, dynamics and function of Survivin revealed by expression of functional SurvivinDsRed fusion proteins in the living cell.
Mol. Biol. Cell., 14, 78-92.
> pubmed

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portrait Michael Rieger

Prof. Dr. Michael Rieger

Curriculum Vitae

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